Chemical genomics for studying parasite gene function and interaction
نویسندگان
چکیده
منابع مشابه
Biochemical microarrays for studying chemical biology interaction: DiscoveryDot technology.
DiscoveryDot is a novel solution-phase technology for chemical compound microarrays which has been validated for several targets (e.g. serine proteases, cysteine proteases, metalloproteinases, histone deacetylases, phosphatases and various kinases) of significance for drug discovery. The historical context of microarrays and the advantages of the DiscoveryDot technology are highlighted. The suc...
متن کاملChemistry for chemical genomics.
New methods and strategies have been developed to design and use small molecules that allow the functional dissection of molecular pathways, cells, and organisms by selective small-molecule ligands or modulators. In this overview, we are focusing on diversity aspects, design methods, and chemical synthesis strategies for the application of small molecules as tools for chemical genomics. Example...
متن کاملParasite Evolutionary Genomics
Development of Nuclear DNA Markers for Evolutionary Studies in Plasmodium falciparum Recent researches in evolutionary genetics have revealed that estimation of genetic diversity is strongly dependent on the genetic markers used, thus making appropriate evolutionary inference at species and gene levels difficult. Considering these facts, we have used published whole-genome sequence information ...
متن کاملA Flexible Bayesian Model for Studying Gene–Environment Interaction
An important follow-up step after genetic markers are found to be associated with a disease outcome is a more detailed analysis investigating how the implicated gene or chromosomal region and an established environment risk factor interact to influence the disease risk. The standard approach to this study of gene-environment interaction considers one genetic marker at a time and therefore could...
متن کاملChemical genomics.
Chemical genomics. By S. Jaroch and H. Weinmann (Editors). Ernst Schering Research Foundation Workshop 58. Pp. VII+173. Berlin: Springer-Verlag, 2006. Price 64.15 Euro. ISBN 103 54
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Parasitology
سال: 2013
ISSN: 1471-4922
DOI: 10.1016/j.pt.2013.10.005